methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate
CAS No.:1062368-32-4
Molecular Formula:C₂₅H₁₉N₃O₃
Molecular Weight:409.444
Hs Code.:

Synonyms:methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate

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Chemical Property of methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate

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Technology Process of methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate

There total 6 articles about methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1062368-31-3
C₁₅H₁₃N₃O₂

: 65192-28-1
2-(4-methoxyphenyl)malondialdehyde

: 1062368-32-4
methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate

Guidance literature:: In acetic acid; at 82 ℃;
DOI:10.1016/j.bmcl.2008.06.052

Reference yield:

: 1062368-29-9
methyl 4-bromo-5-nitro-1H-pyrrole-2-carboxylate

: 1062368-32-4
methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 101 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 0.67 h

3.1: acetic acid / methanol / 82 °C

3.2: 20 °C / Saturated solution

With hydrogen; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In 1,4-dioxane; methanol;

Reference yield:

: 1062368-28-8
4-bromo-5-nitro-2-trichloroacetylpyrrole

: 1062368-32-4
methyl 3-(4-methoxyphenyl)-8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2 h / 20 °C

1.2: 0 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 101 °C

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 0.67 h

4.1: acetic acid / methanol / 82 °C

4.2: 20 °C / Saturated solution

With hydrogen; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In 1,4-dioxane; methanol;