N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Base Information

Chemical Name:N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide
CAS No.:1407519-23-6
Molecular Formula:C₂₂H₂₄N₅O₃P
Molecular Weight:437.438
Hs Code.:

Synonyms:N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

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Chemical Property of N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

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Technology Process of N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

There total 6 articles about N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1407519-22-5
N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

: 1407519-23-6
N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃;

Reference yield:

: 1407520-11-9
(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

: 1407519-23-6
N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; 2-methoxy-ethanol / 5 h / 110 °C / Sealed

2: ammonium chloride / zinc / 1.5 h / 20 °C

3: triethylamine / dichloromethane / 0.25 h / -35 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

With hydrogenchloride; hydrogen; ammonium chloride; triethylamine; palladium 10% on activated carbon; zinc; In ethanol; dichloromethane; 2-methoxy-ethanol;

Reference yield:

: 1407520-12-0
C₁₉H₁₉BrN₅O₄P

: 1407519-23-6
N-(3-((4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride / zinc / 1.5 h / 20 °C

2: triethylamine / dichloromethane / 0.25 h / -35 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

With hydrogen; ammonium chloride; triethylamine; palladium 10% on activated carbon; zinc; In ethanol; dichloromethane;