(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Base Information

Chemical Name:(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
CAS No.:1407520-11-9
Molecular Formula:C₁₂H₁₂BrClN₃OP
Molecular Weight:360.578
Hs Code.:

Synonyms:(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

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Chemical Property of (2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

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Technology Process of (2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

There total 2 articles about (2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 36082-50-5
2,4-dichloro-5-bromopyrimidine

: 1197953-47-1
(2-aminophenyl)dimethyl phosphorus oxide

: 1407520-11-9
(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 8h;
DOI:10.1021/acs.jmedchem.6b00306

Reference yield:

: 615-43-0
2-iodophenylamine

: 1407520-11-9
(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 3 h / 150 °C

2: potassium carbonate / tetra(n-butyl)ammonium hydrogensulfate / N,N-dimethyl-formamide / 7 h / 65 °C

With potassium phosphate; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide;