N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Base Information

Chemical Name:N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide
CAS No.:1407519-22-5
Molecular Formula:C₂₂H₂₃BrN₅O₃P
Molecular Weight:516.334
Hs Code.:

Synonyms:N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

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Chemical Property of N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

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Technology Process of N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

There total 5 articles about N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1407520-13-1
C₁₉H₂₁BrN₅O₂P

: 814-68-6,25189-84-8
acryloyl chloride

: 1407519-22-5
N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Guidance literature:: With triethylamine; In dichloromethane; at -35 ℃; for 0.25h;

Reference yield:

: 615-43-0
2-iodophenylamine

: 1407519-22-5
N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 3 h / 150 °C

2: potassium carbonate / tetra(n-butyl)ammonium hydrogensulfate / N,N-dimethyl-formamide / 7 h / 65 °C

3: hydrogenchloride / ethanol; 2-methoxy-ethanol / 5 h / 110 °C / Sealed

4: ammonium chloride / zinc / 1.5 h / 20 °C

5: triethylamine / dichloromethane / 0.25 h / -35 °C

With hydrogenchloride; potassium phosphate; potassium carbonate; ammonium chloride; triethylamine; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In ethanol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1407520-11-9
(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

: 1407519-22-5
N-(3-((5-bromo-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; 2-methoxy-ethanol / 5 h / 110 °C / Sealed

2: ammonium chloride / zinc / 1.5 h / 20 °C

3: triethylamine / dichloromethane / 0.25 h / -35 °C

With hydrogenchloride; ammonium chloride; triethylamine; zinc; In ethanol; dichloromethane; 2-methoxy-ethanol;