317820-43-2Relevant academic research and scientific papers
2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.
Prakash,Manoharan,Kawasaki,Lesnik,Owens,Vasquez
, p. 3995 - 3998 (2000)
[structure] Oligonucleotides with two novel modifications, 2'-O-2-[N, N-(dimethyl)aminooxy]ethyl (2'-O-DMAOE) and 2'-O-2-[N, N-(diethyl)aminooxy]ethyl (2'-O-DEAOE), have been synthesized. These modifications exhibit high binding affinity to target RNA (and not to DNA) and enhance the nuclease stability of oligonucleotides considerably with t(1/2) > 24 h as a phosphodiester.
