3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide

Base Information

Chemical Name:3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide
CAS No.:1314873-92-1
Molecular Formula:C₂₂H₂₀F₃N₇O₂
Molecular Weight:471.442
Hs Code.:

Synonyms:3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide

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Chemical Property of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide

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Technology Process of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide

There total 8 articles about 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 937026-26-1
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid

: 1314875-01-8
C₁₀H₁₀F₃N₅

: 1314873-92-1
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide

Guidance literature:: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

C₁₀H₁₀F₃N₅; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 7.0%

: 937026-26-1
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid

: C₁₀H₈BrF₃N₄

: 1314873-92-1
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 958245-17-5
1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole

: 1314873-92-1
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[1-methyl-5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C / Inert atmosphere

2.1: sodium nitrite; sulfuric acid / acetic acid / 0.5 h / 10 - 20 °C

2.2: 1 h / 20 °C

3.1: 1,3-bis-(diphenylphosphino)propane; water / palladium diacetate / tetrahydrofuran / 24 h / 150 °C / 15001.5 Torr / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 20 °C

With thiophene; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium nitrite; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;