N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide

Base Information

• Chemical Name: N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide
• CAS No.: 671777-78-9
• Molecular Formula: C₁₃H₁₉NO₂Si
• Molecular Weight: 249.385
• Mol file: 671777-78-9.mol

Synonyms:N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide

Chemical Property of N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide

There total 1 articles about N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

phenylglyoxylyl chloride (25726-04-9) + N-(trimethylsilylmethyl)methylamine (18135-05-2) → N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide (671777-78-9)

Guidance literature:

In dichloromethane; at 25 ℃;

DOI:10.1021/jo030343q

Reference yield: 23.0%

methanol (67-56-1) + N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide (671777-78-9) → N-methyl-2-hydroxy-2-phenylethanamide (65645-88-7,89843-35-6,96392-41-5,2019-72-9) + 2-hydroxy-N-methoxymethyl-N-methyl-2-phenyl-acetamide + 5-phenyl-3-trimethylsilanylmethyl-oxazolidin-4-one + 2-hydroxy-N-methoxymethyl-2-phenyl-N-trimethylsilanylmethyl-acetamide

Guidance literature:

for 3h; Further byproducts given; UV-irradiation;

DOI:10.1021/jo030343q

Reference yield: 22.0%

N-methyl-2-oxo-2-phenyl-N-trimethylsilanylmethyl-acetamide (671777-78-9) → rac-3-hydroxy-1-methyl-3-phenylazetidin-2-one (77184-12-4) + 3-methyl-5-phenyloxazolidin-4-one + 5-hydroxy-3-methyl-5-phenyl-oxazolidin-4-one + 3-hydroxy-1-methyl-3-phenyl-4-trimethylsilanyl-azetidin-2-one

Guidance literature:

In acetonitrile; for 2h; Further byproducts given; UV-irradiation;

DOI:10.1021/jo030343q

upstream raw materials:

phenylglyoxylyl chloride

N-(trimethylsilylmethyl)methylamine

Downstream raw materials:

N-methyl-2-hydroxy-2-phenylethanamide

rac-3-hydroxy-1-methyl-3-phenylazetidin-2-one