(2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

Base Information

Chemical Name:(2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol
CAS No.:129451-96-3
Molecular Formula:C₂₀H₃₂O₄
Molecular Weight:336.472
Hs Code.:

Synonyms:(2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

Suppliers and Price of (2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

Chemical Property:

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Technology Process of (2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

There total 10 articles about (2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 129451-95-2
(2R,3R,4S)-5-(benzyloxy)-3-(hydroxymethyl)-3,4-dimethylpentan-2-ol

: 3282-30-2
pivaloyl chloride

: 129451-96-3
(2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

Guidance literature:: With pyridine; In dichloromethane;
DOI:10.1016/0040-4039(90)80138-C

Reference yield:

: 129451-94-1,141660-88-0,141660-92-6
(2RS,3R,4S,5R)-4-<(1S)-1-<(benzyloxy)methyl>ethyl>-4,5-dimethyltetrahydrofuran-2,3-diol

: 129451-96-3
(2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaIO₄, 2.) NaBH₄ / 1.) MeOH, H₂O, r.t., 3 h, 2.) EtOH, r.t., 1 h

2: 80 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; sodium periodate; In dichloromethane;
DOI:10.1021/jo00040a014

Reference yield:

: 129437-54-3,141660-87-9
(βS,2R,3S,4R,5R)-4,5-(isopropylidenedioxy)-β,2,3-trimethyltetrahydrofuran-3-ethanol

: 129451-96-3
(2R,3R,4S)-5-(benzyloxy)-3,4-dimethyl-3-<(trimethylacetoxy)methyl>pentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, r.t., 30 min, 2.) r.t., overnight

2: 79 percent / 20percent aq. oxalic acid / tetrahydrofuran / 72 h / 50 °C

3: 1.) NaIO₄, 2.) NaBH₄ / 1.) MeOH, H₂O, r.t., 3 h, 2.) EtOH, r.t., 1 h

4: 80 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; sodium periodate; oxalic acid; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00040a014