5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole

Base Information

• Chemical Name: 5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole
• CAS No.: 1333128-04-3
• Molecular Formula: C₁₈H₁₈N₂O
• Molecular Weight: 278.354
• Mol file: 1333128-04-3.mol

Synonyms:5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole

Chemical Property of 5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole

There total 3 articles about 5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1,2-dimethyl-1H-imidazole (1739-84-0) + 4-chloro-(4'-methoxybiphenyl) (58970-19-7) → 5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole (1333128-04-3)

Guidance literature:

With Pd(1,3-dibenzylimidazol-2-ylidene)(PPh₃)(OAc)2; potassium acetate; In N,N-dimethyl acetamide; at 140 ℃; for 18h; Inert atmosphere;

DOI:10.1021/om200490k

Reference yield:

bromochlorobenzene (106-39-8) → 5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole (1333128-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(1,3-dibenzylimidazol-2-ylidene)(PPh₃)(OAc)2; caesium carbonate / 1,4-dioxane / 2 h / 80 °C

2: Pd(1,3-dibenzylimidazol-2-ylidene)(PPh₃)(OAc)2; potassium acetate / N,N-dimethyl acetamide / 18 h / 140 °C / Inert atmosphere

With Pd(1,3-dibenzylimidazol-2-ylidene)(PPh₃)(OAc)2; potassium acetate; caesium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; 1: Suzuki coupling;

DOI:10.1021/om200490k

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → 5-[4-(4-methoxyphenyl)phenyl]-1,2-dimethylimidazole (1333128-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(1,3-dibenzylimidazol-2-ylidene)(PPh₃)(OAc)2; caesium carbonate / 1,4-dioxane / 2 h / 80 °C

2: Pd(1,3-dibenzylimidazol-2-ylidene)(PPh₃)(OAc)2; potassium acetate / N,N-dimethyl acetamide / 18 h / 140 °C / Inert atmosphere

With Pd(1,3-dibenzylimidazol-2-ylidene)(PPh₃)(OAc)2; potassium acetate; caesium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; 1: Suzuki coupling;

DOI:10.1021/om200490k

upstream raw materials:

1,2-dimethyl-1H-imidazole

4-chloro-(4'-methoxybiphenyl)

bromochlorobenzene

4-methoxyphenylboronic acid