(S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one
CAS No.:862283-67-8
Molecular Formula:C₂₈H₂₇ClN₂O₃
Molecular Weight:474.987
Hs Code.:

Synonyms:(S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

There total 3 articles about (S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

: 133729-81-4
(4S)-3-<(2E)-3-(4-chlorophenyl)propenoyl>-4-phenylmethyl-1,3-oxazolidin-2-one

: 862283-67-8
(S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

: (S)-4-benzyl-3-((3R,4S)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1021/jm5011397

Reference yield:

: 35086-79-4,95602-71-4
cinnamoyl chloride

: 862283-67-8
(S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; lithium chloride / dichloromethane / 0.25 h / 5 °C

2: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; lithium chloride; In dichloromethane;
DOI:10.1021/jm5011397

Reference yield:

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 862283-67-8
(S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 24 h / 0 - 20 °C

2: triethylamine; lithium chloride / dichloromethane / 0.25 h / 5 °C

3: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium chloride; In dichloromethane;
DOI:10.1021/jm5011397