AKOS BBS-00007039

Base Information

• Chemical Name: AKOS BBS-00007039
• CAS No.: 1093649-88-7
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.185
• Mol file: 1093649-88-7.mol

Synonyms:5-(4-hydroxyphenyl)-1H-pyrazole-3-carboxylic acid

Chemical Property of AKOS BBS-00007039

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Hydroxyphenyl)-1H-pyrazole-5-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of AKOS BBS-00007039

There total 6 articles about AKOS BBS-00007039 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-(4-hydroxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (96472-12-7) → 5-(4-hydroxyphenyl)-1H-pyrazole-3-carboxylic acid (1093649-88-7)

Guidance literature:

5-(4-hydroxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid (27069-16-5) → 5-(4-hydroxyphenyl)-1H-pyrazole-3-carboxylic acid (1093649-88-7)

Guidance literature:

With boron tribromide; In dichloromethane; at -20 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.12.094

Reference yield:

4-Hydroxyacetophenone (99-93-4) → 5-(4-hydroxyphenyl)-1H-pyrazole-3-carboxylic acid (1093649-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / methanol / 15 h / 20 °C

2: acetic acid; hydrazine hydrate / 20 °C

With sodium methylate; hydrazine hydrate; acetic acid; In methanol;

DOI:10.1016/j.bmc.2015.05.052

upstream raw materials:

5-(4-hydroxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

4-Hydroxyacetophenone

phenol

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

5-(4-hydroxy-phenyl)-1H-pyrazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-amide

5-(4-hydroxyphenyl)-1H-pyrazole-3-carboxylic acid {2-[4-(2-chlorophenylamino)piperidin-1-yl]-2-oxoethyl}amide

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