Valeryl-4-hydroxyvalsartan

Base Information

Chemical Name:Valeryl-4-hydroxyvalsartan
CAS No.:188259-69-0
Molecular Formula:C₂₄H₂₉N₅O₄
Molecular Weight:451.525
Hs Code.:
UNII:N891C54AXX
Nikkaji Number:J809.841G
Wikidata:Q27284701
Metabolomics Workbench ID:42503
Mol file:188259-69-0.mol

Synonyms:188259-69-0;Valeryl-4-hydroxyvalsartan;4-hydroxy valsartan;4-Hydroxyvalsartan;N891C54AXX;CGP-71580;UNII-N891C54AXX;(2S)-2-[4-hydroxypentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-3-methylbutanoic acid;L-Valine, N-(4-hydroxy-1-oxopentyl)-N-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-;L-Valine, N-(4-hydroxy-1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-;SCHEMBL3473667;CHEBI:165851;ICSQZMPILLPFKC-XLDIYJRPSA-N;AKOS040754785;PD120067;Q27284701;(2S)-2-[4-hydroxy-N-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]-3-methylbutanoic acid;(S)-2-{(4-Hydroxy-pentanoyl)-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amino}-3-methyl-butyric acid

Suppliers and Price of Valeryl-4-hydroxyvalsartan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-HydroxyValsartan(MixtureofDiastereomers)
25mg
$ 1390.00

TRC
4-HydroxyValsartan(MixtureofDiastereomers)
2.5mg
$ 180.00

Cayman Chemical
4-hydroxy Valsartan
2.5mg
$ 325.00

American Custom Chemicals Corporation
4-HYDROXY VALSARTAN 95.00%
25MG
$ 2243.59

American Custom Chemicals Corporation
4-HYDROXY VALSARTAN 95.00%
2.5MG
$ 952.88

Total 12 raw suppliers

Chemical Property of Valeryl-4-hydroxyvalsartan

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:130-132°C
Refractive Index:1.6
Boiling Point:733.738°C at 760 mmHg
Flash Point:397.551°C
PSA：132.30000
Density:1.265g/cm³
LogP:3.13250
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:Methanol (Slightly)
XLogP3:3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:451.22195442
Heavy Atom Count:33
Complexity:640

Purity/Quality:

98%Min ^*data from raw suppliers

4-HydroxyValsartan(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(=O)CCC(C)O
Isomeric SMILES:CC(C)[C@@H](C(=O)O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(=O)CCC(C)O
Description 4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.
Uses A nonpeptide angiotensin II AT1-receptor antagonist A nonpeptide angiotensin II AT1-receptor antagonist.

Technology Process of Valeryl-4-hydroxyvalsartan

There total 5 articles about Valeryl-4-hydroxyvalsartan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 188240-33-7
(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

: 188259-69-0
4-Hydroxyvalsartan

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1080/004982597240767

Reference yield:

: 1490-24-0
4-oxo-pentanoyl chloride

: 188259-69-0
4-Hydroxyvalsartan

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / diisopropylethylamine / CH₂Cl₂

2: 41 percent / tri-n-butyl tin azide / xylene / Heating

3: 89 percent / 10 percent Pd/C / tetrahydrofuran

4: 94 percent / NaBH₄ / methanol

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; azido tributyltin (IV); palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; xylene; 1: Acylation / 2: Cyclization / 3: Hydrogenation / 4: Reduction;
DOI:10.1080/004982597240767

Reference yield:

: 188240-31-5
(S)-N-(4-Oxo-valeryl)-N-[(2'-cyano-biphenyl-4-yl)methyl]valine benzyl ester

: 188259-69-0
4-Hydroxyvalsartan

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / tri-n-butyl tin azide / xylene / Heating

2: 89 percent / 10 percent Pd/C / tetrahydrofuran

3: 94 percent / NaBH₄ / methanol

With sodium tetrahydroborate; azido tributyltin (IV); palladium on activated charcoal; In tetrahydrofuran; methanol; xylene; 1: Cyclization / 2: Hydrogenation / 3: Reduction;
DOI:10.1080/004982597240767