(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

Base Information

Chemical Name:(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine
CAS No.:188240-33-7
Molecular Formula:C₂₄H₂₇N₅O₄
Molecular Weight:449.509
Hs Code.:

Synonyms:(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

Suppliers and Price of (S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

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Technology Process of (S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

There total 4 articles about (S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 188240-32-6
(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine benzyl ester

: 188240-33-7
(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

Guidance literature:: palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1080/004982597240767

Reference yield:

: 1490-24-0
4-oxo-pentanoyl chloride

: 188240-33-7
(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / diisopropylethylamine / CH₂Cl₂

2: 41 percent / tri-n-butyl tin azide / xylene / Heating

3: 89 percent / 10 percent Pd/C / tetrahydrofuran

With N-ethyl-N,N-diisopropylamine; azido tributyltin (IV); palladium on activated charcoal; In tetrahydrofuran; dichloromethane; xylene; 1: Acylation / 2: Cyclization / 3: Hydrogenation;
DOI:10.1080/004982597240767

Reference yield:

: 188240-31-5
(S)-N-(4-Oxo-valeryl)-N-[(2'-cyano-biphenyl-4-yl)methyl]valine benzyl ester

: 188240-33-7
(S)-N-(4-Oxo-valeryl)-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]valine

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / tri-n-butyl tin azide / xylene / Heating

2: 89 percent / 10 percent Pd/C / tetrahydrofuran

With azido tributyltin (IV); palladium on activated charcoal; In tetrahydrofuran; xylene; 1: Cyclization / 2: Hydrogenation;
DOI:10.1080/004982597240767