N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide

Base Information

• Chemical Name: N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide
• CAS No.: 1613152-71-8
• Molecular Formula: C₆₄H₆₆N₄O₈
• Molecular Weight: 1019.25

Synonyms:N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide

Chemical Property of N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide

Chemical Property:

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Technology Process of N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide

There total 7 articles about N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1,10-decanedioic acid (111-20-6,26776-29-4) + 3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one (1613152-67-2) → N1,N10-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide (1613152-71-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

N-(4-(4-(4-methoxyphenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide (1613152-62-7) → N1,N10-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide (1613152-71-8)

Guidance literature:

Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 1 h

2: potassium carbonate / acetone / Reflux

3: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

4: hydrogenchloride / water; ethanol / Reflux

5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

4-aminophenylacetic acid (1197-55-3) → N1,N10-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide (1613152-71-8)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / Reflux

2: boron tribromide / dichloromethane / 1 h

3: potassium carbonate / acetone / Reflux

4: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

5: hydrogenchloride / water; ethanol / Reflux

6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 1: |Perkin Coumarin Rearrangement;

DOI:10.1016/j.bmcl.2014.04.106

upstream raw materials:

4-aminophenylacetic acid

(2-hydroxyphenyl)(4-methoxyphenyl)methanone

N-(4-(4-(4-methoxyphenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide

1,10-decanedioic acid

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