N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide

Base Information

Chemical Name:N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide
CAS No.:312283-39-9
Molecular Formula:C₂₈H₄₀N₄O₆SSi
Molecular Weight:588.8
Hs Code.:

Synonyms:N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide

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Chemical Property of N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide

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Technology Process of N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide

There total 6 articles about N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 312283-38-8
N-[3-(2-nitrobenzenesulfonyl)amino-propan-1-yl]-1H-indole-3-acetamide

: 312283-39-9
N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; caesium carbonate; In acetonitrile; at 60 ℃; for 1.5h;
DOI:10.1248/cpb.48.1570

Reference yield:

: 87-51-4
indole-3-acetic acid

: 312283-39-9
N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.05 h / 20 °C

2: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 0.17 h / 20 °C

3: 80 percent / Cs₂CO₃; nBu₄NI / acetonitrile / 1.5 h / 60 °C

With dmap; tetra-(n-butyl)ammonium iodide; caesium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1248/cpb.48.1570

Reference yield:

: 125213-31-2
C₁₅H₁₇NO₃

: 312283-39-9
N-(7-tert-butyldimethylsilyloxy-4-(2-nitrobenzenesulfonyl)-4-azaheptan-1-yl)-1H-indole-3-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 0.17 h / 20 °C

2: 80 percent / Cs₂CO₃; nBu₄NI / acetonitrile / 1.5 h / 60 °C

With dmap; tetra-(n-butyl)ammonium iodide; caesium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1248/cpb.48.1570