2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol

Base Information

• Chemical Name: 2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol
• CAS No.: 1201890-45-0
• Molecular Formula: C₁₀H₈BrF₃O₃
• Molecular Weight: 313.071
• Mol file: 1201890-45-0.mol

Synonyms:2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol

Chemical Property of 2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol

There total 1 articles about 2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-4-(4-bromophenyl)-1,1,1-trifluoro-3-buten-2-one (366014-14-4) → 2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol (1201890-45-0)

Guidance literature:

With 4-benzyloxy-α,α-bis-(3,5-dimethylphenyl)-D-prolinol; tert.-butylhydroperoxide; In hexane; toluene; at 0 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.200900041

Reference yield: 85.0%

2,2,2-trifluoro-1-((2S,3R)-3-(4-bromophenyl)oxiran-2-yl)ethane-1,1-diol (1201890-45-0) + phenylhydrazine (100-63-0) → (3R,4S,5S)-5-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)pyrazolidine-3,4-diol (1201890-53-0)

Guidance literature:

In ethanol; at -15 ℃; for 3h;

DOI:10.1002/adsc.200900041

upstream raw materials:

(E)-4-(4-bromophenyl)-1,1,1-trifluoro-3-buten-2-one

Downstream raw materials:

(3R,4S,5S)-5-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)pyrazolidine-3,4-diol