(4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester

Base Information

Chemical Name:(4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester
CAS No.:1598382-72-9
Molecular Formula:C₂₁H₁₈ClF₇N₂O₃
Molecular Weight:514.827
Hs Code.:

Synonyms:(4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester

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Chemical Property of (4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester

Chemical Property:

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Technology Process of (4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester

There total 9 articles about (4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1598382-71-8
(S)-1,1,1-trifluoro-3-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-yl]-propan-2-ol

: 104-12-1
p-chlorphenylisocyanate

: 1598382-72-9
(4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester

: 1598383-38-0
C₂₁H₁₉ClF₆N₂O₃

Guidance literature:: In toluene; at 90 - 95 ℃; for 6h; Overall yield = 241 mg;

Reference yield:

: 208173-24-4
1-(4-fluoro-3-(trifluoromethyl)phenyl)ethanone

: 1598382-72-9
(4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester

: 1598383-38-0
C₂₁H₁₉ClF₆N₂O₃

Guidance literature:: Multi-step reaction with 9 steps

1: acetonitrile / 5 h / Reflux

2: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 1.5 h / 20 °C

3: sodium azide / dimethyl sulfoxide / 3 h / 80 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 h

5: sodium hydrogencarbonate / dichloromethane; water / 0.58 h / Cooling with ice

6: sodium hydride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

7: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 0 - 20 °C / Cooling with ice

8: 60 °C

9: toluene / 6 h / 90 - 95 °C

With lithium aluminium tetrahydride; sodium azide; borane-THF; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: 1598382-64-9
toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

: 1598382-72-9
(4-chlorophenyl)carbamic acid (S)-2,2,2-trifluoro-1-[(R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester

: 1598383-38-0
C₂₁H₁₉ClF₆N₂O₃

Guidance literature:: Multi-step reaction with 8 steps

1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 1.5 h / 20 °C

2: sodium azide / dimethyl sulfoxide / 3 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 h

4: sodium hydrogencarbonate / dichloromethane; water / 0.58 h / Cooling with ice

5: sodium hydride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

6: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 0 - 20 °C / Cooling with ice

7: 60 °C

8: toluene / 6 h / 90 - 95 °C

With lithium aluminium tetrahydride; sodium azide; borane-THF; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene;