toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester
CAS No.:1598382-64-9
Molecular Formula:C₁₆H₁₂F₄O₄S
Molecular Weight:376.328
Hs Code.:

Synonyms:toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

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Chemical Property of toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

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Technology Process of toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

There total 1 articles about toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27126-76-7
[hydroxy(tosyloxy)iodo]benzene

: 208173-24-4
1-(4-fluoro-3-(trifluoromethyl)phenyl)ethanone

: 1598382-64-9
toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

Guidance literature:: In acetonitrile; for 5h; Reflux;

Reference yield:

: 1598382-64-9
toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

: 1598382-65-0
toluene-4-sulfonic acid (R)-2-(4-fluoro-3-trifluoromethyl-phenyl)-2-hydroxyethyl ester

Guidance literature:: With borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

: 1598382-64-9
toluene-4-sulfonic acid 2-(4-fluoro-3-trifluoromethyl-phenyl)-2-oxo-ethyl ester

: 1598382-70-7
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)morpholine

Guidance literature:: Multi-step reaction with 6 steps

1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 1.5 h / 20 °C

2: sodium azide / dimethyl sulfoxide / 3 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 h

4: sodium hydrogencarbonate / dichloromethane; water / 0.58 h / Cooling with ice

5: sodium hydride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

6: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 0 - 20 °C / Cooling with ice

With lithium aluminium tetrahydride; sodium azide; borane-THF; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide;