(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate

Base Information

• Chemical Name: (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate
• CAS No.: 116132-52-6
• Molecular Formula: C₂₄H₂₉NO₃
• Molecular Weight: 379.499
• Mol file: 116132-52-6.mol

Synonyms:(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate

Chemical Property of (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate

There total 6 articles about (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-methoxyphenyl)-2-phenylpropanoyl chloride (19842-21-8) + 3-tropanol (120-29-6) → (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate (116132-52-6)

Guidance literature:

In toluene; at 100 ℃; for 3h;

Reference yield:

3-tropanol (120-29-6) → (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate (116132-52-6)

Guidance literature:

With benzene; at 70 ℃;

Reference yield:

benzeneacetic acid methyl ester (101-41-7) → (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(4-methoxyphenyl)-2-phenylpropanoate (116132-52-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C

1.2: 5 - 20 °C

2.1: sodium hydroxide; water / methanol; tetrahydrofuran / 18 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 0 - 20 °C

4.1: toluene / 3 h / 100 °C

With oxalyl dichloride; potassium tert-butylate; water; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

upstream raw materials:

3-tropanol

3-(4-methoxyphenyl)-2-phenylpropanoyl chloride

benzeneacetic acid methyl ester

p-Methoxybenzyl bromide