4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

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Chemical Name:4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine
CAS No.:388573-33-9
Molecular Formula:C₃₁H₂₉N₇O₃
Molecular Weight:547.616
Hs Code.:

Synonyms:4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

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Chemical Property of 4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

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Technology Process of 4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

There total 12 articles about 4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 388573-30-6
(2-chloro-4-methoxypyridin-3-yl)-bis-[2-(methylsulfayl)pyrimidin-4-yl]methanol

: 388573-33-9
4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 308 mg / tetrahydrofuran / 20 °C

2: 75 percent / triethylsilane; trifluoroacetic acid / 1,2-dichloro-ethane / 26 h / 80 °C

3: m-CPBA / CHCl₃ / -40 °C

4: 43 mg / 15 h / 85 °C

With triethylsilane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane;
DOI:10.1021/jo050523v

Reference yield:

: 388573-31-7
4-methoxy-9-(methylsulfanyl)-5-[2-(methylsulfanyl)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

: 388573-33-9
4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: m-CPBA / CHCl₃ / -40 °C

2: 43 mg / 15 h / 85 °C

With 3-chloro-benzenecarboperoxoic acid; In chloroform;
DOI:10.1021/jo050523v

Reference yield:

: 864229-51-6
ethyl 2-chloro-4-methoxypyridine-3-carboxylate

: 388573-33-9
4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1.49 g / NaOH / 0.5 h

2.1: 97 percent / oxalyl chloride / CH₂Cl₂; dimethylformamide / 19 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -95 °C

3.2: 383 mg / tetrahydrofuran; hexane / 4.5 h / -95 °C

4.1: 308 mg / tetrahydrofuran / 20 °C

5.1: 75 percent / triethylsilane; trifluoroacetic acid / 1,2-dichloro-ethane / 26 h / 80 °C

6.1: m-CPBA / CHCl₃ / -40 °C

7.1: 43 mg / 15 h / 85 °C

With triethylsilane; sodium hydroxide; n-butyllithium; oxalyl dichloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050523v