4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Base Information

Chemical Name:4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine
CAS No.:388573-34-0
Molecular Formula:C₃₀H₂₇N₇O₃
Molecular Weight:533.589
Hs Code.:

Synonyms:4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Suppliers and Price of 4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

There total 16 articles about 4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 388573-33-9
4-methoxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

: 388573-34-0
4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: With sodium thioethylate; In N,N-dimethyl-formamide; at 55 ℃; for 7h;
DOI:10.1016/S0040-4039(01)01881-0

Reference yield:

: 394729-98-7
2-chloro-4-methoxynicotinic acid

: 388573-34-0
4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 97 percent / oxalyl chloride / CH₂Cl₂; dimethylformamide / 19 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -95 °C

2.2: 383 mg / tetrahydrofuran; hexane / 4.5 h / -95 °C

3.1: 308 mg / tetrahydrofuran / 20 °C

4.1: 75 percent / triethylsilane; trifluoroacetic acid / 1,2-dichloro-ethane / 26 h / 80 °C

5.1: m-CPBA / CHCl₃ / -40 °C

6.1: 43 mg / 15 h / 85 °C

7.1: 95 percent / sodium ethanethiolate / dimethylformamide / 7.5 h / 55 °C

With triethylsilane; n-butyllithium; oxalyl dichloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium thioethylate; In tetrahydrofuran; hexane; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050523v

Reference yield:

: 388573-30-6
(2-chloro-4-methoxypyridin-3-yl)-bis-[2-(methylsulfayl)pyrimidin-4-yl]methanol

: 388573-34-0
4-hydroxy-9-(4-methoxybenzylamino)-5-[2-(4-methoxybenzylamino)pyrimidin-4-yl]pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 308 mg / tetrahydrofuran / 20 °C

2: 75 percent / triethylsilane; trifluoroacetic acid / 1,2-dichloro-ethane / 26 h / 80 °C

3: m-CPBA / CHCl₃ / -40 °C

4: 43 mg / 15 h / 85 °C

5: 95 percent / sodium ethanethiolate / dimethylformamide / 7.5 h / 55 °C

With triethylsilane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium thioethylate; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050523v