dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

Base Information

• Chemical Name: dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate
• CAS No.: 1346177-32-9
• Molecular Formula: C₂₃H₁₇BrN₄O₅
• Molecular Weight: 509.316
• Mol file: 1346177-32-9.mol

Synonyms:dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

Chemical Property of dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

There total 2 articles about dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + dimethyl acetylenedicarboxylate (762-42-5) + 4-bromo-aniline (106-40-1) + malononitrile (109-77-3) → dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate (1346177-32-9)

Guidance literature:

With molybdenum complex on cross-linked poly(1-aminopropyl-3-vinylimidazolium bromide)entrapped cobalt oxide nanoparticles; In water; at 20 ℃; for 0.2h; regioselective reaction; Sonication;

DOI:10.1016/j.ultsonch.2021.105614

Reference yield: 85.0%

2-oxo-2,3-dihydroindolylidenemalononitrile (6623-89-8) + dimethyl acetylenedicarboxylate (762-42-5) + 4-bromo-aniline (106-40-1) → dimethyl 2'-amino-1'-(4-bromophenyl)-3'-cyano-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate (1346177-32-9)

Guidance literature:

dimethyl acetylenedicarboxylate; 4-bromo-aniline; With 1,4-diazabicyclo[2.2.2]octane hydroacetate; In ethanol; at 40 ℃; for 0.166667h;

2-oxo-2,3-dihydroindolylidenemalononitrile; In ethanol; at 40 ℃; for 5h;

DOI:10.1039/c9gc03639c

upstream raw materials:

indole-2,3-dione

dimethyl acetylenedicarboxylate

4-bromo-aniline

malononitrile