methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate
CAS No.:1396123-93-5
Molecular Formula:C₁₃H₁₁F₃N₂O₂
Molecular Weight:284.238
Hs Code.:

Synonyms:methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

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Chemical Property of methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

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Technology Process of methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

There total 7 articles about methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1396123-83-3
3-phenyl-4-(trifluoromethyl)-1,2,3-λ⁵-oxadiazol-3-ium-5-olate

: 23326-27-4
Methyl 2-butynoate

: 1396123-93-5
methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

: methyl 3-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: In 1,2-dichloro-benzene; at 180 ℃; for 24h; Sealed tube;
DOI:10.1021/ol3021918

Reference yield:

: 622-37-7
Phenyl azide

: 1396123-93-5
methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

: methyl 3-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 2 h / 20 °C

2: toluene / 2 h / 20 °C

3: lithium iodide / ethyl acetate / 4 h / Reflux

4: isopentyl nitrite / 1,2-dimethoxyethane / 5 h / 20 °C

5: trifluoroacetic anhydride / dichloromethane / 1 h / 0 - 20 °C

6: 1,2-dichloro-benzene / 24 h / 180 °C / Sealed tube

With trifluoroacetic anhydride; lithium iodide; isopentyl nitrite; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-benzene; toluene;
DOI:10.1021/ol3021918

Reference yield:

: 2325-27-1
N-phenyltriphenyliminophosphorane

: 1396123-93-5
methyl 4-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate

: methyl 3-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / 20 °C

2: lithium iodide / ethyl acetate / 4 h / Reflux

3: isopentyl nitrite / 1,2-dimethoxyethane / 5 h / 20 °C

4: trifluoroacetic anhydride / dichloromethane / 1 h / 0 - 20 °C

5: 1,2-dichloro-benzene / 24 h / 180 °C / Sealed tube

With trifluoroacetic anhydride; lithium iodide; isopentyl nitrite; In 1,2-dimethoxyethane; dichloromethane; ethyl acetate; 1,2-dichloro-benzene; toluene;
DOI:10.1021/ol3021918