(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide

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Chemical Name:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide
CAS No.:1375277-42-1
Molecular Formula:C₂₉H₃₀N₄O₄
Molecular Weight:498.582
Hs Code.:

Synonyms:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide

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Chemical Property of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide

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Technology Process of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide

There total 3 articles about (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.9%

: 1375278-70-8
2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetic acid

: 1375278-62-8
(S)-2-amino-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-3-phenylpropanamide

: 1375277-42-1
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 65645-56-9
2-methyl-1H-pyrrolo[2,3-c]pyridine

: 1375277-42-1
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil / 0.5 h / 20 °C

2.1: 0.5 h / 0 °C

2.2: 0.5 h

3.1: triethylsilane; trifluoroacetic acid / tetrahydrofuran / 3 h / 55 °C

4.1: water; sodium hydroxide / methanol / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With triethylsilane; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 3430-27-1
3-amino-4-methylpyridine

: 1375277-42-1
(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)acetamido)-N-methyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sec.-butyllithium / tetrahydrofuran / 2 h / -78 °C

1.2: 3 h / -78 °C

1.3: 12 h / Reflux

2.1: sodium hydride / mineral oil / 0.5 h / 20 °C

3.1: 0.5 h / 0 °C

3.2: 0.5 h

4.1: triethylsilane; trifluoroacetic acid / tetrahydrofuran / 3 h / 55 °C

5.1: water; sodium hydroxide / methanol / 3 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With triethylsilane; water; sec.-butyllithium; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;