4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride

Base Information

Chemical Name:4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride
CAS No.:142549-69-7
Molecular Formula:C₂₃H₂₅N₃O₇*ClH
Molecular Weight:491.928
Hs Code.:

Synonyms:4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride

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Chemical Property of 4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride

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Technology Process of 4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride

There total 6 articles about 4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

: 142549-61-9
4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester

: 142549-69-7
4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; chloroform; for 1.5h; Heating;
DOI:10.1248/cpb.40.899

Reference yield:

: 142549-46-0
4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester

: 142549-69-7
4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / K₂CO₃ / dimethylformamide / 19 h / Ambient temperature

2: 98.4 percent / NaI, K₂CO₃ / dimethylformamide / 3 h

3: 63.1 percent / m-chloroperbenzoic acid / CHCl₃ / 1 h

4: 83.7 percent / 1 N aq. NaOH / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

5: 1.) NaH, 2.) Et₃N / 1.) DMF, RT, 20 min, 2.) DMF, 100 deg C, 13 h

6: 98.4 percent / HCl / methanol; CHCl₃ / 1.5 h / Heating

With hydrogenchloride; sodium hydroxide; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.899

Reference yield:

: 142549-51-7
4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 3-methyl ester

: 142549-69-7
4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, 2.) Et₃N / 1.) DMF, RT, 20 min, 2.) DMF, 100 deg C, 13 h

2: 98.4 percent / HCl / methanol; CHCl₃ / 1.5 h / Heating

With hydrogenchloride; sodium hydride; triethylamine; In methanol; chloroform;
DOI:10.1248/cpb.40.899