4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester

Base Information

• Chemical Name: 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester
• CAS No.: 142549-47-1
• Molecular Formula: C₁₉H₁₉ClN₂O₈
• Molecular Weight: 438.821
• Mol file: 142549-47-1.mol

Synonyms:4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester

Chemical Property of 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester

There total 1 articles about 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloromethyl methyl ether (107-30-2) + 4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester (142549-46-0) → 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester (142549-47-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 19h; Ambient temperature;

DOI:10.1248/cpb.40.899

Reference yield: 98.4%

thiophenol (108-98-5) + 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester (142549-47-1) → 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 3-methyl ester 1-(2-phenylsulfanyl-ethyl) ester (142549-48-2)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; for 3h;

DOI:10.1248/cpb.40.899

Reference yield:

4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester (142549-47-1) → 4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 3-methyl ester (142549-51-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 98.4 percent / NaI, K₂CO₃ / dimethylformamide / 3 h

2: 63.1 percent / m-chloroperbenzoic acid / CHCl₃ / 1 h

3: 83.7 percent / 1 N aq. NaOH / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

With sodium hydroxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.40.899

upstream raw materials:

chloromethyl methyl ether

4-Hydroxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-chloro-ethyl) ester 3-methyl ester

Downstream raw materials:

4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 3-methyl ester 1-(2-phenylsulfanyl-ethyl) ester

4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 3-methyl ester

4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(4-diethylamino-but-2-ynyl) ester 3-methyl ester

4-Methoxymethoxy-6-methyl-2-(3-nitro-pyridin-2-yl)-isophthalic acid 1-(2-benzenesulfonyl-ethyl) ester 3-methyl ester