8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline

Base Information

Chemical Name:8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline
CAS No.:1608477-71-9
Molecular Formula:C₂₅H₂₂FN₃O₄S₂
Molecular Weight:511.598
Hs Code.:

Synonyms:8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline

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Chemical Property of 8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline

Chemical Property:

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Technology Process of 8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline

There total 5 articles about 8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607742-69-8
3-(phenylsulfonyl)-8-(piperazin-1-yl)quinoline

: 2905-21-7
2-fluorobenzenesulfonyl chloride

: 1608477-71-9
8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm500372e

Reference yield:

: 1429304-29-9
8-chloro-3-(phenylsulfonyl)quinoline

: 1608477-71-9
8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; sodium t-butanolate / toluene / 110 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; trifluoroacetic acid; sodium t-butanolate; DavePhos; In dichloromethane; toluene;
DOI:10.1021/jm500372e

Reference yield:

: 847727-21-3
8-chloro-3-iodo-quinoline

: 1608477-71-9
8-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-3-(phenylsulfonyl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: N,N`-dimethylethylenediamine; caesium carbonate; copper(l) iodide / dimethyl sulfoxide / 4 h / 110 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; sodium t-butanolate / toluene / 110 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; caesium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; DavePhos; N,N`-dimethylethylenediamine; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm500372e