(E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide

Base Information

Chemical Name:(E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide
CAS No.:1331884-87-7
Molecular Formula:C₂₁H₁₇Cl₂F₃N₂O₃
Molecular Weight:473.279
Hs Code.:

Synonyms:(E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide

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Chemical Property of (E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide

Chemical Property:

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Technology Process of (E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide

There total 16 articles about (E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331886-78-2
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

: 593-56-6
N-methoxylamine hydrochloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1331884-87-7
(E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide

Guidance literature:: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid; N,N-dimethyl-formamide dimethyl acetal; for 0.5h; Inert atmosphere; Reflux;

N-methoxylamine hydrochloride; With acetic acid; sodium hydroxide; In water; at 20 ℃; for 1h;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1331884-87-7
(E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

1.2: 0.5 h / 2 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8.2 h / 20 °C / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

4.1: 0.5 h / Inert atmosphere; Reflux

4.2: 1 h / 20 °C

With oxalyl dichloride; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In dichloromethane; toluene;

Reference yield:

: 445003-37-2
4-bromo-2-methyl-benzoic acid tert-butyl ester

: 1331884-87-7
(E)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-N-[(methoxyimino)methyl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8.2 h / 20 °C / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

3.1: 0.5 h / Inert atmosphere; Reflux

3.2: 1 h / 20 °C

With trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene;