2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester

Base Information

• Chemical Name: 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester
• CAS No.: 144068-34-8
• Molecular Formula: C₃₂H₅₂O₅Si
• Molecular Weight: 544.847
• Mol file: 144068-34-8.mol

Synonyms:2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester

Chemical Property of 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester

There total 3 articles about 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-p-methoxybenzyloxypropionic acid (144068-33-7) + [1R-[1β,[αS*,βS*],3aα,4aβ,7aβ]]-octahydro-β,7a-dimethyl-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-ethenyl-1H-indene-1-ethanol (93489-72-6) → 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester (144068-34-8)

Guidance literature:

With 4 A molecular sieve; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In dichloromethane;

DOI:10.1039/c39920001229

Reference yield:

2-(4-Methoxy-benzyloxy)-propionic acid ethyl ester (144401-98-9) → 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester (144068-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / methanol

2: 93 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (morpho CDI), 4 A molecular sieves / CH₂Cl₂

With sodium hydroxide; 4 A molecular sieve; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In methanol; dichloromethane;

DOI:10.1039/c39920001229

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester (144068-34-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Ag₂O / diethyl ether

2: NaOH / methanol

3: 93 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (morpho CDI), 4 A molecular sieves / CH₂Cl₂

With sodium hydroxide; 4 A molecular sieve; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; silver(l) oxide; In methanol; diethyl ether; dichloromethane;

DOI:10.1039/c39920001229

upstream raw materials:

2-p-methoxybenzyloxypropionic acid

[1R-[1β,[αS*,βS*],3aα,4aβ,7aβ]]-octahydro-β,7a-dimethyl-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-ethenyl-1H-indene-1-ethanol

2-(4-Methoxy-benzyloxy)-propionic acid ethyl ester

p-methoxybenzyl chloride

Downstream raw materials:

(3R,5S)-5-{(R)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-propyl}-3-(4-methoxy-benzyloxy)-3-methyl-dihydro-furan-2-one

(E)-(R)-6-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-2-(4-methoxy-benzyloxy)-2-methyl-hept-4-enoic acid

(3R,5R)-5-{(1S,2S)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-1-iodo-propyl}-3-(4-methoxy-benzyloxy)-3-methyl-dihydro-furan-2-one

(3R,5S)-5-{(1R,2S)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-1-iodo-propyl}-3-(4-methoxy-benzyloxy)-3-methyl-dihydro-furan-2-one