(S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Base Information

Chemical Name:(S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide
CAS No.:1214265-32-3
Molecular Formula:C₂₀H₂₄F₂N₄O₄
Molecular Weight:422.432
Hs Code.:

Synonyms:(S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

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Chemical Property of (S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

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Technology Process of (S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

There total 12 articles about (S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-96-4
ethyl bromide

: 1214265-29-8
(S)-N-{{3-[3,5-difluoro-4-(7-hydroxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

: 1214265-32-3
(S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 129321-60-4
5,8-dioxa-10-azadispiro[2.0.44.33]undecane

: 1214265-32-3
(S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: acetonitrile / Reflux

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h / 2068.65 Torr

3.1: sodium hydrogencarbonate / water; acetone / 20 °C / Ice bath

4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

4.2: -78 - 20 °C

5.1: triethylamine / dichloromethane / 20 °C / Ice bath

6.1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

7.1: hydrogen / palladium on activated charcoal / ethyl acetate / 14 h / 20 °C / 760.05 Torr

8.1: pyridine / 2.5 h / 0 - 20 °C / Inert atmosphere

9.1: water; toluene-4-sulfonic acid / acetone / 3 h / Reflux

10.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

11.1: potassium hydroxide / N,N-dimethyl-formamide / 0 °C

With pyridine; n-butyllithium; sodium azide; hydroxylamine hydrochloride; water; hydrogen; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1214265-36-7
C₁₄H₁₆F₂N₂O₂

: 1214265-32-3
(S)-N-{{3-[3,5-difluoro-4-(7-ethoxyimino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate / water; acetone / 20 °C / Ice bath

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: -78 - 20 °C

3.1: triethylamine / dichloromethane / 20 °C / Ice bath

4.1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

5.1: hydrogen / palladium on activated charcoal / ethyl acetate / 14 h / 20 °C / 760.05 Torr

6.1: pyridine / 2.5 h / 0 - 20 °C / Inert atmosphere

7.1: water; toluene-4-sulfonic acid / acetone / 3 h / Reflux

8.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

9.1: potassium hydroxide / N,N-dimethyl-formamide / 0 °C

With pyridine; n-butyllithium; sodium azide; hydroxylamine hydrochloride; water; hydrogen; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;