N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide

Base Information

Chemical Name:N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide
CAS No.:1132936-43-6
Molecular Formula:C₂₃H₂₄N₄O₅S₂
Molecular Weight:500.599
Hs Code.:

Synonyms:N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide

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Chemical Property of N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide

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Technology Process of N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide

There total 4 articles about N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1132936-42-5
1-(3-tert-butyl-5-(2-aminobenzo[d]thiazol-6-yl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

: 124-63-0
methanesulfonyl chloride

: 1132936-43-6
N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1132936-41-4
1-(3-tert-butyl-5-(2-(2,5-dimethyl-1H-pyrrol-1-yl)benzo[d]thiazol-6-yl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

: 124-63-0
methanesulfonyl chloride

: 1132936-43-6
N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide

Guidance literature:: 1-(3-tert-butyl-5-(2-(2,5-dimethyl-1H-pyrrol-1-yl)benzo[d]thiazol-6-yl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione; With trifluoroacetic acid; In water; at 80 ℃; for 2.5h;

methanesulfonyl chloride; With pyridine; In dichloromethane; at 25 ℃; for 16h;
DOI:10.1016/j.bmcl.2013.04.057

Reference yield:

: 88-18-6
2-tert-Butylphenol

: 1132936-43-6
N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzo[d]thiazol-2-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; sodium iodide; sodium hypochlorite / methanol

1.2: 48 h / 25 °C

1.3: 18 h / 60 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 1 h / 100 °C / Microwave irradiation

3.1: trifluoroacetic acid / water / 2.5 h / 80 °C

3.2: 16 h / 25 °C

With sodium hypochlorite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; trifluoroacetic acid; sodium iodide; sodium hydroxide; In methanol; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2013.04.057