154822-66-9

Basic information

• Product Name: Isoxazole, 4-(4-methoxyphenyl)-3,5-dimethyl-
• CAS NO: 154822-66-9
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.241
• Mol File: 154822-66-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Isoxazole, 4-(4-methoxyphenyl)-3,5-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 4-(4-methoxyphenyl)-3,5-dimethyl-(154822-66-9)
• EPA Substance Registry System: Isoxazole, 4-(4-methoxyphenyl)-3,5-dimethyl-(154822-66-9)

Safety Data

• Hazardous Substances Data: 154822-66-9(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 10558-25-5 4-bromo-3,5-dimethyl-1,2-oxazole 
• 10557-85-4 4-iodo-3,5-dimethylisoxazole 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1160169-22-1 (Z)-4-amino-3-(4-methoxyphenyl)pent-3-en-2-one 
• 72969-10-9 3-(4'-methoxyphenyl)-pentane-2,4-dione 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 1160169-36-7 1-(2-(4-methoxyphenyl)-3-methyl-2H-azirin-2-yl)ethanone 
• 79-24-3 Nitroethane 
• 105-13-5 4-Methoxybenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1355554-13-0 N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-hydroxybenzenesulfonamide 
• 1355554-31-2 N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide 
• 1227693-30-2 5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzene-1-sulfonyl chloride 
• 1355770-63-6 (rac)-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-(piperidin-3-yl) benzenesulfonamide hydrochloride 
• 1355555-63-3 5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-(piperidin-4-yl)benzenesulfonamide hydrochloride 
• 1355770-59-0 4-(4-methoxy-3-(piperazin-1-ylsulfonyl)phenyl)-3,5-dimethylisoxazole 
• 132572-89-5 3-(4-Methoxyphenyl)pentane-2,4-dione 

Relevant articles and documents

Simple Synthesis of Symmetrical 4-Substituted 3,5-Dialkylisoxazoles

A number of symmetrical 4-substituted 3,5-dialkylrsoxazoles have been prepared by treatment of aromatic aldehydes with nitroalkanes and aqueous sodium hydroxide.

Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia

Accumulating researches have contributed much effect to discover novel chemotherapeutic drug for leukemia with expeditious curative effect, of which bromodomain-containing protein 4 (BRD4) inhibitor is considered as a eutherapeutic drug which has presented efficient cell proliferation suppression effect. In this study, we disclosed a series of phenylisoxazole sulfonamide derivatives as potent BRD4 inhibitors. Especially, compound 58 exhibited robust inhibitory potency toward BRD4-BD1 and BRD4-BD2 with IC50 values of 70 and 140 nM, respectively. In addition, compound 58 significantly suppressed cell proliferation of leukemia cell lines HL-60 and MV4-11 with IC50 values of 1.21 and 0.15 μM. In-depth study of the biological mechanism of compound 58 exerted its tumor suppression effect via down-regulating the level of oncogene c-myc. Moreover, in vivo pharmacokinetics (PK) study was conducted and the results demonstrated better pharmacokinetics features versus (+)-JQ1. In summary, our study discovers that compound 58 represents as a novel BRD4 inhibitor for further investigation in development of leukemia inhibitor with potentiality.

Ferrocenyl palladacycles derived from unsymmetrical pincer-type ligands: Evidence of Pd(0) nanoparticle generation during the Suzuki-Miyaura reaction and applications in the direct arylation of thiazoles and isoxazoles

A new family of ferrocenyl-palladacycle complexes Pd(L1)Cl (Pd1) and Pd(L2)Cl (Pd2) were synthesized and characterized by UV-visible, IR, ESI-MS, and NMR spectral studies. The molecular structures of Pd1 and Pd2 were determined by X-ray crystallographic studies. Palladacycle catalyzed Suzuki-Miyaura cross-coupling reactions were investigated utilizing the derivatives of phenylboronic acids and substituted chlorobenzenes. Mechanistic investigation authenticated the generation of Pd(0) nanoparticles during the catalytic cycle and the nanoparticles were characterized by XPS, SEM and TEM analysis. Direct C-H arylation of thiazole and isoxazole derivatives employing these ferrocenyl-palladacycle complexes was examined. The reaction model for the arylation reaction implicating the in situ generation of Pd(0) nanoparticles was proposed.