Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester
CAS No.:136289-09-3
Molecular Formula:C₄₅H₅₄N₅O₁₀P
Molecular Weight:855.925
Hs Code.:

Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

Synonyms:Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

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Chemical Property of Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

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Technology Process of Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

There total 6 articles about Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 136289-06-0
Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

: 136289-09-3
Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

: 926-65-8
vinyl isopropyl ether

: 136289-09-3
Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonic acid (PPTS) / CH₂Cl₂

2: 1M TEAHF / tetrahydrofuran

3: 55 percent / pyridine / 3 h / 0 °C

4: 80 percent / N,N-diisopropylethylamine / tetrahydrofuran

With pyridine; pyridinium p-toluenesulfonate; tetraethylammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 136289-09-3
Carbonic acid (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-4-(1-isopropoxy-ethoxy)-tetrahydro-furan-2-ylmethyl ester 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / pyridine / 3 h / 0 °C

2: 80 percent / N,N-diisopropylethylamine / tetrahydrofuran

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;