tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1424336-92-4
Molecular Formula:C₂₃H₃₁ClN₄O₄
Molecular Weight:462.977
Hs Code.:

Synonyms:tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 1 articles about tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 27631-29-4
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

: 273207-53-7
tert-butyl (endo)-3-aminomethyl-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1424336-92-4
tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 20 ℃;
DOI:10.1016/j.bmc.2012.12.013

Reference yield:

: 5470-49-5
4-methanesulfonylphenylamine

: 1424336-92-4
tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

: C₂₅H₃₁N₅O₄S

Guidance literature:: 4-methanesulfonylphenylamine; tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate; With hydrogenchloride; In water; butan-1-ol; at 130 ℃;

With sodium hydroxide; In water; butan-1-ol;
DOI:10.1016/j.bmc.2012.12.013

Reference yield:

: 1424336-92-4
tert-butyl exo-3-((2-chloro-6,7-dimethoxyquinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1424336-97-9
tert-butyl exo-3-((6,7-dimethoxy-2-(4-(methylsulfonyl)phenylamino)quinazolin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / butan-1-ol; water / 130 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; water; butan-1-ol;
DOI:10.1016/j.bmc.2012.12.013