N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

Base Information

Chemical Name:N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt
CAS No.:1268385-06-3
Molecular Formula:C₃₂H₂₆F₅N₆O₇*Na
Molecular Weight:724.576
Hs Code.:

N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

Synonyms:N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

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Chemical Property of N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

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Technology Process of N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

There total 10 articles about N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1268383-58-9
N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine

: 1268385-06-3
N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

Guidance literature:: With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 1234790-81-8
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde

: 1268385-06-3
N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydroxylamine / ethanol; water / 2 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

2.2: Reflux

3.1: periodic acid / acetonitrile / 0 - 20 °C

3.2: 0 - 20 °C

4.1: thionyl chloride / 20 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

7.1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

8.1: periodic acid / acetonitrile / 0 - 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1.5 h / 20 °C

10.1: sodium hydrogencarbonate / acetonitrile; water

With N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); hydroxylamine; sodium hydrogencarbonate; potassium carbonate; periodic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrachloromethane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1234790-83-0
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde oxime

: 1268385-06-3
N-{3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoyl}-L-alanine sodium salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

1.2: Reflux

2.1: periodic acid / acetonitrile / 0 - 20 °C

2.2: 0 - 20 °C

3.1: thionyl chloride / 20 °C

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

6.1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

7.1: periodic acid / acetonitrile / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1.5 h / 20 °C

9.1: sodium hydrogencarbonate / acetonitrile; water

With N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; potassium carbonate; periodic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrachloromethane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;