2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid

Base Information

Chemical Name:2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid
CAS No.:127102-44-7
Molecular Formula:C₂₉H₃₁NO₇
Molecular Weight:505.568
Hs Code.:

Synonyms:2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid

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Chemical Property of 2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid

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Technology Process of 2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid

There total 11 articles about 2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127086-85-5
2-(S)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanol

: 127102-44-7
2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 0 ℃; for 2h;
DOI:10.1021/ja00175a039

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 127102-44-7
2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / conc. H₂SO₄ / Heating

2: 90 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

3: 99 percent / trifluoracetic acid / CH₂Cl₂ / Ambient temperature

4: 3.63 g / NaIO₄, RuCl₃ dihydrate / acetonitrile; CCl₄; H₂O / 2 h / 0 °C

With ruthenium trichloride; sodium periodate; sulfuric acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00175a039

Reference yield:

: 41997-33-5
iso-propyl 4-hydroxyphenylacetate

: 127102-44-7
2(R)-(N-carbobenzyloxy-N-methylamino)-3(R)-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>-1-propanocarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

2: 99 percent / trifluoracetic acid / CH₂Cl₂ / Ambient temperature

3: 3.63 g / NaIO₄, RuCl₃ dihydrate / acetonitrile; CCl₄; H₂O / 2 h / 0 °C

With ruthenium trichloride; sodium periodate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00175a039