4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile

Base Information

• Chemical Name: 4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile
• CAS No.: 943827-04-1
• Molecular Formula: C₂₀H₁₆N₄OS
• Molecular Weight: 360.439

Synonyms:4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile

Chemical Property of 4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile

Chemical Property:

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Technology Process of 4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile

There total 5 articles about 4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-[4-(4-hydroxymethyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benzonitrile (500293-65-2) → 4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile (943827-04-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/j.ejmech.2006.11.014

Reference yield:

4-bromo-2,6-dimethylbenzenethiol (89981-04-4) → 4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile (943827-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / sodium hydride; N-methyl-2-pyrrolidone / dioxane / 150 °C

2: 47 percent / triphenylphosphine; K₂CO₃ / Pd(OAc)2 / dimethylformamide / 72 h / 90 °C / 7500.75 Torr

3: 45 percent / LiAlH₄ / tetrahydrofuran / 20 h / 0 - 20 °C

4: 96 percent / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

With 1-methyl-pyrrolidin-2-one; manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2006.11.014

Reference yield:

4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile (244768-32-9) → 4-[4-(4-formyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benznitrile (943827-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / sodium hydride; N-methyl-2-pyrrolidone / dioxane / 150 °C

2: 47 percent / triphenylphosphine; K₂CO₃ / Pd(OAc)2 / dimethylformamide / 72 h / 90 °C / 7500.75 Torr

3: 45 percent / LiAlH₄ / tetrahydrofuran / 20 h / 0 - 20 °C

4: 96 percent / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

With 1-methyl-pyrrolidin-2-one; manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triphenylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2006.11.014

upstream raw materials:

4-[4-(4-hydroxymethyl-2,6-dimethylphenylsulfanyl)pyrimidin-2-ylamino]benzonitrile

4-[2-(4-cyanophenylamino)pyrimidin-4-ylsulfanyl]-3,5-dimethylbenzoic acid ethyl ester

4-bromo-2,6-dimethylbenzenethiol

4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile

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