(+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane

Base Information

• Chemical Name: (+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane
• CAS No.: 192461-74-8
• Molecular Formula: C₂₆H₂₇NO
• Molecular Weight: 369.506

Synonyms:(+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane

Chemical Property of (+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane

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Technology Process of (+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane

There total 8 articles about (+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(-)-(1R)-8-phenylmenthyl (1R,3-exo)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-carboxylate (212073-01-3) + phenylmagnesium bromide → (+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane (192461-74-8)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1016/j.tet.2006.06.118

Reference yield: 87.0%

(-)-(1R)-8-phenylisoneomenthyl (1R,3-exo)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-carboxylate (913255-92-2) + phenylmagnesium bromide → (+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane (192461-74-8)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1016/j.tet.2006.06.118

Reference yield: 60.0%

benzyl bromide (100-39-0) + (1R,3S,4S)-2-azabicyclo<2.2.1>heptane-3-exo-diphenylmethanol (169888-75-9) → (+)-(1R,3-exo)-2-benzyl-3-[(hydroxy)diphenylmethyl]-2-azabicyclo[2.2.1]heptane (192461-74-8)

Guidance literature:

With triethylamine; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1016/S0957-4166(97)00118-3

upstream raw materials:

benzyl bromide

(1R,3S,4S)-2-azabicyclo<2.2.1>heptane-3-exo-diphenylmethanol

(-)-(1R)-8-phenylmenthyl (1R,3-exo)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-carboxylate

(-)-(1R)-8-phenylisoneomenthyl (1R,3-exo)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-carboxylate

Downstream raw materials:

(+)-(1R)-2-benzyl-3-(diphenylmethylidene)-2-azabicyclo[2.2.1]heptane

(+)-(1R)-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

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