Technology Process of (R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate
There total 4 articles about (R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
(Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate;
In
methanol; dichloromethane;
at 20 ℃;
for 16h;
under 3102.97 - 3361.55 Torr;
- Guidance literature:
-
With
(-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen;
In
tetrahydrofuran; dichloromethane;
at 20 ℃;
for 16h;
under 3102.97 - 3361.55 Torr;
Inert atmosphere;
DOI:10.1021/jm800546t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Iodine monochloride; sodium hydrogencarbonate / methanol; dichloromethane / 4 h / 20 °C
1.2: -15 °C
2.1: triethylamine; palladium diacetate; tetrabutyl-ammonium chloride / tetrahydrofuran / 3.5 h / 80 °C / Inert atmosphere; Reflux
3.1: (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen / methanol; dichloromethane / 16 h / 20 °C / 3102.97 Torr / Inert atmosphere
With
(-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; tetrabutyl-ammonium chloride; hydrogen; palladium diacetate; Iodine monochloride; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
2.1: |Heck Reaction;
