(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

Base Information

Chemical Name:(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate
CAS No.:855778-39-1
Molecular Formula:C₂₀H₂₄N₂O₄
Molecular Weight:356.422
Hs Code.:

Synonyms:(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

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Chemical Property of (R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

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Technology Process of (R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

There total 4 articles about (R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 855778-38-0
(Z)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonylamino)acrylate

: 855778-39-1
(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

Guidance literature:: With hydrogen; (Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate; In methanol; dichloromethane; at 20 ℃; for 16h; under 3102.97 - 3361.55 Torr;

Reference yield: 98.0%

: methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonylamino)acrylate

: 855778-39-1
(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

Guidance literature:: With (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h; under 3102.97 - 3361.55 Torr; Inert atmosphere;
DOI:10.1021/jm800546t

Reference yield:

: 87-62-7
2,6-dimethylaniline

: 855778-39-1
(R)-methyl 3-(4-amino-3,5-dimethylphenyl)-2-(benzyloxycarbonyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Iodine monochloride; sodium hydrogencarbonate / methanol; dichloromethane / 4 h / 20 °C

1.2: -15 °C

2.1: triethylamine; palladium diacetate; tetrabutyl-ammonium chloride / tetrahydrofuran / 3.5 h / 80 °C / Inert atmosphere; Reflux

3.1: (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen / methanol; dichloromethane / 16 h / 20 °C / 3102.97 Torr / Inert atmosphere

With (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate; tetrabutyl-ammonium chloride; hydrogen; palladium diacetate; Iodine monochloride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 2.1: |Heck Reaction;