(3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide

Base Information

• Chemical Name: (3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide
• CAS No.: 147802-41-3
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 147802-41-3.mol

Synonyms:(3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide

Chemical Property of (3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide

There total 6 articles about (3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium methylate (124-41-4) + C59H89NO21 → (3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide (147802-41-3)

Guidance literature:

With methanol; at 28 ℃; for 1h;

DOI:10.1080/14786419.2021.1897590

Reference yield:

(25R)-27-O-<(S)-3-hydroxy-3-methylglutaryl>-spirost-5-ene-3β,27-diol 3-O-2)-β-D-glucopyranoside> → (3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide (147802-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 15.0 mg / NaOMe / 1 h / Ambient temperature

2: 1.9 mg / dicyclohexylcarbodiimide / CH₂Cl₂ / 0.5 h / Ambient temperature

With sodium methylate; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/0031-9422(93)85472-4

Reference yield:

(25R)-27-O-<(S)-3-hydroxy-3-methylglutaryl>-spirost-5-ene-3β,27-diol 3-O-2)-<β-D-glucopyranosyl-(1->3)>-β-D-glucopyranoside> → (3S)-1-<(S)-Phenylethyl>-5-methoxy-3-hydroxy-3-methylglutaroamide (147802-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.2 mg / NaOMe / methanol / 1 h / Ambient temperature

2: 1.9 mg / dicyclohexylcarbodiimide / CH₂Cl₂ / 0.5 h / Ambient temperature

With sodium methylate; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1016/0031-9422(93)85472-4

upstream raw materials:

diazomethane

(S)-1-phenyl-ethylamine

((R)-2-Methyl-4-oxo-oxetan-2-yl)-acetic acid

3-hydroxy-3-methylglutaric anhydride

Downstream raw materials:

(3R)-5-O-acetyl-1-<(S)-phenylethyl>-mevalonamide

(3R)-1-[(S)-1-phenylethyl]mevalonamide