3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile

Base Information

Chemical Name:3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile
CAS No.:1355995-66-2
Molecular Formula:C₂₀H₁₈F₂N₂O₂S
Molecular Weight:388.438
Hs Code.:

Synonyms:3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile

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Chemical Property of 3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile

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Technology Process of 3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile

There total 6 articles about 3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: C₂₀H₂₁F₂NO₃S

: 1355995-66-2
3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile

Guidance literature:: trimethylsilyl cyanide; C₂₀H₂₁F₂NO₃S; With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.25h;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃;
DOI:10.1016/j.tetlet.2011.11.105

Reference yield:

: C₁₉H₂₁F₂NO₃S

: 1355995-66-2
3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 0.75 h / 0 - 20 °C

1.2: 20 °C

2.1: N-Bromosuccinimide / 2 h / Reflux

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 10 h / Reflux

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / 20 °C

4.2: 20 °C

With N-Bromosuccinimide; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2011.11.105

Reference yield:

: 349625-89-4
ethyl 1-(methylsulfonyl)piperidine-3-carboxylate

: 1355995-66-2
3-[bis(4-fluorophenyl)methylene]-1-(methylsulfonyl)piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 5 h / 20 °C / Cooling with ice

1.2: 20 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 0.75 h / 0 - 20 °C

2.2: 20 °C

3.1: N-Bromosuccinimide / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 10 h / Reflux

5.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / 20 °C

5.2: 20 °C

With N-Bromosuccinimide; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; 1.1: Grignard reaction;
DOI:10.1016/j.tetlet.2011.11.105