2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile

Base Information

Chemical Name:2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile
CAS No.:1451067-59-6
Molecular Formula:C₂₉H₃₂N₂O₆
Molecular Weight:504.583
Hs Code.:

Synonyms:2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile

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Chemical Property of 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile

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Technology Process of 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile

There total 6 articles about 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 58042-53-8
9-(2-bromoethoxy)-7H-furo[3,2-g]chromen-7-one

: 27487-66-7
D 620

: 1451067-59-6
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile

Guidance literature:: With potassium carbonate; In acetonitrile; for 72h; Reflux;
DOI:10.1080/10286020.2013.874345

Reference yield:

: 27487-83-8
2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile

: 1451067-59-6
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia; potassium iodide / water; ethanol / 120 h / 50 °C

2: potassium carbonate / acetonitrile / 72 h / Reflux

With ammonia; potassium carbonate; potassium iodide; In ethanol; water; acetonitrile;
DOI:10.1080/10286020.2013.874345

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 1451067-59-6
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-((2-((2-oxo-2H-furo[3,2-g]chromen-9-yl)oxy)ethyl)amino)pentanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; dimethyl sulfoxide / 48 h / 20 °C

2.1: sodium amide / toluene / 2 h / Reflux; Inert atmosphere

2.2: 48 h / 50 °C / Reflux; Inert atmosphere

3.1: ammonia; potassium iodide / water; ethanol / 120 h / 50 °C

4.1: potassium carbonate / acetonitrile / 72 h / Reflux

With ammonia; potassium carbonate; sodium amide; potassium iodide; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1080/10286020.2013.874345