(2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal

Base Information

Chemical Name:(2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal
CAS No.:1374453-69-6
Molecular Formula:C₂₉H₅₁NO₄SSi₄
Molecular Weight:622.136
Hs Code.:

Synonyms:(2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal

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Chemical Property of (2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal

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Technology Process of (2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal

There total 3 articles about (2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: Z-tris(trimethylsilyl)-propenyloxy-silane

: 197247-27-1
N-benzyl-4-methyl-N-(1-oxopropan-2-yl)benzenesulfonamide

: 1374453-69-6
(2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal

Guidance literature:: With bis(trifluoromethanesulfonyl)amide; In dichloromethane; at -78 ℃; for 1.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201108325

Reference yield:

: 150081-96-2
tris(trimethylsilyl)silyl trifluoromethanesulfonate

: 1374453-69-6
(2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 - 17 °C / Inert atmosphere

2: bis(trifluoromethanesulfonyl)amide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

With bis(trifluoromethanesulfonyl)amide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/anie.201108325

Reference yield:

: 1873-77-4
tris-(trimethylsilyl)silane

: 1374453-69-6
(2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0 - 17 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 - 17 °C / Inert atmosphere

3: bis(trifluoromethanesulfonyl)amide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

With bis(trifluoromethanesulfonyl)amide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/anie.201108325