197247-27-1

Upstream product

• 100-39-0 benzyl bromide 
• 31022-10-3 N-benzyl-L-alanine methyl ester 
• 100-52-7 benzaldehyde 
• 209266-15-9 (S)-N-benzyl-2-(p-tolylsulfonyl-amino)propanol 
• 209266-08-0 (S)-methyl N-benzyl-N-tosylalaninate 

Downstream Products

• 497968-31-7 (1S,2S)-N-benzyl-N-[2-(5-methylfuran-2-yl)-2-hydroxy-1-methylethyl]-4-methylbenzenesulfonamide 
• 209266-15-9 (S)-N-benzyl-2-(p-tolylsulfonyl-amino)propanol 
• 1374452-49-9 (2R,3R,4S,5S,6S)-N-benzyl-N-(4-methylbenzenesulfonyl)-5-amino-2,4-dimethyl-3,5-bis(tris(trimethylsilyl)silyloxy)heptanal 
• 1374453-69-6 (2S,3R,4S)-N-(4-methylbenzenesulfonyl)-N-benzyl-4-amino-2-methyl-3-tris(trimethylsilyl)siloxypentanal 
• 782496-38-2 (2S,5S,1'R,4'R,5'S)-N-tert-butoxycarbonyl-5-(tert-butyldiphenylsilyloxy)methyl-2-[N'-benzyl-5'-(p-tolylsulfonyl)amino-1',4'-dihydroxy]-2'-hexynyl-pyrrolidine 
• 782496-39-3 (2S,5S,1'R,4'R,5'S)-N-tert-butoxycarbonyl-5-(tert-butyldiphenylsilyloxy)methyl-2-[N'-benzyl-5'-(p-tolylsulfonyl)amino-1',4'-hydroxy]-hexyl-pyrrolidine 
• 782496-36-0 (2S,5S,1'R,4'R,5'S)-N-tert-butoxycarbonyl-5-(tert-butyldiphenylsilyloxy)methyl-2-[N'-benzyl-5'-(p-tolylsulfonyl)amino-4'-hydroxy-1'-(trimethylsilyl)oxy]-2'-hexynyl-pyrrolidine 

Relevant academic research and scientific papers

Stereoselective synthesis of trans-threo-trans-oligopyrrolidines: Potential agents for RNA cleavage

The 2,5-trans-substituted oligopyrrolidines constitute a promising class of novel RNA-binding agents as well as potential building blocks for artificial anion channels. A convergent synthesis of terpyrrolidine 1 and pyrrolidino-THF-pyrrolidine 2 is reported, relying upon convergent coupling of 2,5-trans-pyrrolidinecarboxaldehydes through bridging alkyne units under Felkin-Anh control and subsequent closure of the central ring. After complete deprotection, the free polyamine products were isolated in excellent yield and purity. Crystal structure analyses of a terpyrrolidine and a pyrrolidino-THF-pyrrolidine documented their helical privileged conformations. The compounds were then screened for RNA cleavage activity. Unlike the only weakly active simple polyamines, p-nitrosulfonamide 33 was found to induce cleavage at mM concentrations under physiologically relevant conditions.

Effective and mild method for preparation of optically active α-amino aldehydes via TEMPO oxidation

The TEMPO oxidation method is successfully applied to preparation of variously protected, optically active α-amino aldehydes without racemization and in very good yield.

Diastereoselective addition of vinylmagnesium halides to variously N-mono- and N,N-diprotected L-alaninals

Diastereoselective C2-elongation processes of N-mono- 1a-c and N,N-diprotected 1d-f L-alaninals, using vinylmagnesium bromide and chloride, are described. A substantial difference between effects of the N-protecting groups replacing either one