(S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

Base Information

Chemical Name:(S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide
CAS No.:1290050-56-4
Molecular Formula:C₂₄H₃₀ClF₃N₄O₅
Molecular Weight:546.974
Hs Code.:

(S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

Synonyms:(S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

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Chemical Property of (S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

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Technology Process of (S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

There total 17 articles about (S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1290048-71-3
(S)-1-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-3-methyl-piperazin-2-one

: 39893-50-0
3-chloro-4-trifluoromethylphenyl isocyanate

: 1290050-56-4
(S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

Guidance literature:: (S)-1-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-3-methyl-piperazin-2-one; With 4-methyl-morpholine; In dichloromethane; at 20 ℃;

3-chloro-4-trifluoromethylphenyl isocyanate; In dichloromethane; for 1h;

Reference yield:

: 159635-22-0
3-hydroxy-4-methylene-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

: 1290050-56-4
(S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethylzinc / toluene; 1,2-dichloro-ethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -70 - -60 °C

2.2: 0.17 h / -60 °C

3.1: sodium hydroxide; magnesium(II) chloride hexahydrate; α-D-glucose monohydrate / ketoreductase KRED-NADH-117; glucose dehydrogenase GDH-102 / 35 °C / pH 6.5 / Aqueous buffer

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 1 h / 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol

7.1: 4-methyl-morpholine / dichloromethane / 20 °C

7.2: 1 h

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; magnesium(II) chloride hexahydrate; hydrogen; diethylzinc; α-D-glucose monohydrate; dimethyl sulfoxide; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 2.1: Swern Oxidation / 2.2: Swern Oxidation;

Reference yield:

: 1101840-72-5
tert-butyl 4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate

: 1290050-56-4
(S)-4-[(R,S)-3-hydroxy-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -70 - -60 °C

1.2: 0.17 h / -60 °C

2.1: sodium hydroxide; magnesium(II) chloride hexahydrate; α-D-glucose monohydrate / ketoreductase KRED-NADH-117; glucose dehydrogenase GDH-102 / 35 °C / pH 6.5 / Aqueous buffer

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 1 h / 20 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol

6.1: 4-methyl-morpholine / dichloromethane / 20 °C

6.2: 1 h

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; magnesium(II) chloride hexahydrate; hydrogen; α-D-glucose monohydrate; dimethyl sulfoxide; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Swern Oxidation / 1.2: Swern Oxidation;