cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate

Base Information

Chemical Name:cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate
CAS No.:901768-35-2
Molecular Formula:C₂₅H₃₀FN₃O₄S*H₂O
Molecular Weight:505.611
Hs Code.:

Synonyms:cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate

Suppliers and Price of cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate

There total 1 articles about cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.14%

: 834868-88-1
syn-N-(4-amino-cyclohexyl)-2-(tetrahydrothiopyran-4-yloxy)-nicotinamide hydrochloride

: 50-85-1
2-hydroxy-p-toluic acid

: 901768-35-2
cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate

Guidance literature:: syn-N-(4-amino-cyclohexyl)-2-(tetrahydrothiopyran-4-yloxy)-nicotinamide hydrochloride; 2-hydroxy-p-toluic acid; With benzotriazol-1-ol; triethylamine; In Isopropyl acetate; for 2h; Heating / reflux;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In Isopropyl acetate; at 40 ℃; for 24h; Heating / reflux;

With water; In Isopropyl acetate; at 0 - 25 ℃; for 19h;