cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide

Base Information

Chemical Name:cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide
CAS No.:901768-34-1
Molecular Formula:C₂₅H₃₀FN₃O₄S
Molecular Weight:487.595
Hs Code.:

Synonyms:cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide

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Chemical Property of cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide

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Technology Process of cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide

There total 3 articles about cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 901768-35-2
cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide monohydrate

: 901768-34-1
cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide

Guidance literature:: In acetonitrile; at 0 - 20 ℃; Heating / reflux;

Reference yield:

: 834868-88-1
syn-N-(4-amino-cyclohexyl)-2-(tetrahydrothiopyran-4-yloxy)-nicotinamide hydrochloride

: 50-85-1
2-hydroxy-p-toluic acid

: 901768-34-1
cis-5-fluoro-N-[4-(2-hydroxy-4-methylbenzamido)cyclohexyl]-2-(tetrahydro-thiopyran-4-yloxy)-nicotinamide

Guidance literature:: syn-N-(4-amino-cyclohexyl)-2-(tetrahydrothiopyran-4-yloxy)-nicotinamide hydrochloride; 2-hydroxy-p-toluic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 73.5h;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

With hydrogenchloride; In dichloromethane; water;