(1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

Base Information

Chemical Name:(1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one
CAS No.:217820-20-7
Molecular Formula:C₄₁H₇₀O₁₀Si₂
Molecular Weight:779.172
Hs Code.:

(1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

Synonyms:(1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

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Chemical Property of (1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

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Technology Process of (1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

There total 6 articles about (1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 217820-18-3
(1S,2R,4S,5S,7S,8S)-7,8-dihydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

: 217820-20-7
(1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo981749j

Reference yield:

: 217820-14-9
(2S,4R,5S)-2-(4-Methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-4-vinyl-[1,3]dioxane-5-carbaldehyde

: 217820-20-7
(1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium hexamethyldisilazide / 1.) THF, room temperature, 10 min, 2.) THF

2: 1.) n-butyllithium / 1.) ether, pentane, 5 min, 2.) ether, pentane, 20 min

3: 1.) 18-crown-6, potassium hexamethyldisilazide / 1.) THF, toluene, -78 -> -30 deg C, 2.) THF, toluene, 2 h

4: 41 percent / pyridine, osmium tetraoxide / 2 h

5: 73 percent / imidazole, 4-(N,N-dimethylamino)pyridine / dimethylformamide / Ambient temperature

With pyridine; 1H-imidazole; dmap; osmium(VIII) oxide; n-butyllithium; 18-crown-6 ether; sodium hexamethyldisilazane; potassium hexamethylsilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jo981749j

Reference yield:

: 217820-15-0
<2-<<<(2S,4R,5S)-5-<(Z)-2-iodovinyl>-2-(p-methoxyphenyl)-4-vinyl-m-dioxan-5-yl>oxy>methoxy>ethyl>trimethylsilane

: 217820-20-7
(1S,2R,4S,5S,7S,8S)-7-(tert-butyldimethylsiloxy)-8-hydroxy-2-(methoxymethoxy)-5-<(2S,4R,5S)-2-(p-methoxyphenyl)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-4-vinyl-m-dioxan-5-yl>-4,11,11-trimethylbicyclo<6.2.1>undecan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium / 1.) ether, pentane, 5 min, 2.) ether, pentane, 20 min

2: 1.) 18-crown-6, potassium hexamethyldisilazide / 1.) THF, toluene, -78 -> -30 deg C, 2.) THF, toluene, 2 h

3: 41 percent / pyridine, osmium tetraoxide / 2 h

4: 73 percent / imidazole, 4-(N,N-dimethylamino)pyridine / dimethylformamide / Ambient temperature

With pyridine; 1H-imidazole; dmap; osmium(VIII) oxide; n-butyllithium; 18-crown-6 ether; potassium hexamethylsilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jo981749j