5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide

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Chemical Name:5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide
CAS No.:949926-06-1
Molecular Formula:C₂₄H₃₇N₃O₄S₂
Molecular Weight:495.707
Hs Code.:

Synonyms:5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide

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Chemical Property of 5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide

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Technology Process of 5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide

There total 6 articles about 5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 949926-06-1
5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / EDCI; NMM / CH₂Cl₂ / 0 - 20 °C

2: LiALH₄ / diethyl ether / 0 °C

3: CH₂Cl₂ / 20 °C

4: TFA / CH₂Cl₂ / 0 - 20 °C

5: Et₃N / CH₂Cl₂ / 20 °C

6: HBTU; DIPEA / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3: Passerini reaction;
DOI:10.1016/j.bmcl.2005.08.064

Reference yield:

: 949925-79-5
(S)-2-Amino-N-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethyl)-3-methyl-butyramide

: 1077-28-7,62-46-4
Thioctic acid

: 949926-06-1
5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2005.08.064

Reference yield:

: (S)-2-Amino-3-methyl-butyric acid (S)-2-amino-1-ethylcarbamoyl-2-phenyl-ethyl ester

: 949926-06-1
5-[1,2]Dithiolan-3-yl-pentanoic acid [(S)-1-((S)-2-ethylcarbamoyl-2-hydroxy-1-phenyl-ethylcarbamoyl)-2-methyl-propyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: HBTU; DIPEA / dimethylformamide / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.08.064