7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

Base Information

Chemical Name:7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one
CAS No.:949891-80-9
Molecular Formula:C₁₉H₂₀BrFN₂O₂
Molecular Weight:407.282
Hs Code.:

Synonyms:7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

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Chemical Property of 7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

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Technology Process of 7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

There total 10 articles about 7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 949891-78-5
7-Bromo-8-chloromethyl-1,3,3-trimethyl-3,4-dihydro-1 H-quinoxalin-2-one

: 452-85-7
5-fluoro-2-methylphenol

: 949891-80-9
7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 82.0%

: 949891-76-3
7-Bromo-8-hydroxymethyl-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

: 452-85-7
5-fluoro-2-methylphenol

: 949891-80-9
7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 20 ℃; for 1.33333h;

Reference yield:

: 6942-36-5
methyl 2-bromo-5-nitrobenzoate

: 949891-80-9
7-bromo-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: tin(ll) chloride; methanol / 2 h / Reflux

2: triethylamine / dichloromethane / 2.5 h / 0 °C / Cooling with ice

3: nitric acid; sulfuric acid / 1.5 h / 0 °C

4: boron trifluoride diethyl etherate; methanol / 2.5 h / Reflux

5: potassium iodide; caesium carbonate / 96 h / 85 °C

6: ethanol; tin(ll) chloride / 5 h / Reflux

7: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

8: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

9: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 1.33 h / 20 °C

With methanol; lithium aluminium tetrahydride; ethanol; tributylphosphine; sulfuric acid; boron trifluoride diethyl etherate; nitric acid; caesium carbonate; triethylamine; potassium iodide; tin(ll) chloride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;